3-Fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)benzoic acid → N-Cyclopropyl-3-fluoro-N-(3'-fluoro-5'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-4-(5-methyl-[1,2,4]triazol-1-yl)-benzamide

HRID 68890ノート

反応式

HRID 68890 の反応式
[CH:1]1([NH:4][CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[C:16]([F:17])=[CH:15][C:14]([C:18]([F:21])([F:20])[F:19])=[CH:13][N:12]=3)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1.[F:22][C:23]1[CH:24]=[C:25]([CH:29]=[CH:30][C:31]=1[N:32]1[C:36]([CH3:37])=[N:35][CH:34]=[N:33]1)[C:26](O)=[O:27]>>[CH:1]1([N:4]([CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[C:16]([F:17])=[CH:15][C:14]([C:18]([F:20])([F:19])[F:21])=[CH:13][N:12]=3)[CH2:7][CH2:6]2)[C:26](=[O:27])[C:25]2[CH:29]=[CH:30][C:31]([N:32]3[C:36]([CH3:37])=[N:35][CH:34]=[N:33]3)=[C:23]([F:22])[CH:24]=2)[CH2:2][CH2:3]1

参加物

3

反応物 2

HCID 682895893-Fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)benzoic acidHCID 68289864Cyclopropyl-(3'-fluoro-5'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-amine

生成物 1

HCID 68351910N-Cyclopropyl-3-fluoro-N-(3'-fluoro-5'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-4-(5-methyl-[1,2,4]triazol-1-yl)-benzamide

実験手順

The title compound is prepared from cyclopropyl-(3′-fluoro-5′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-amine and 3-fluoro-4-(5-methyl-[1,2,4]triazol-1-yl)-benzoic acid following a procedure analogous to that described in Example 90. LC (method 19): tR=4.64 min; Mass spectrum (ESI+): m/z=507 [M+H]+.

出典と根拠

ORDレコード
ord-737f8f435b7a43d3b66b72d42a1cb781
出典データセット
uspto-grants-2014_09
特許番号
US08822471B2

反応ノート

読み込み中…