1-(5-chloropyrimidin-2-yl)-N-cyclopropylpiperidin-4-amine → N-[1-(5-Chloro-pyrimidin-2-yl)-piperidin-4-yl]-N-cyclopropyl-3-fluoro-4-(5-methyl-[1,2,4]triazol-1-yl)-benzamide

HRID 68909ノート

反応式

HRID 68909 の反応式
[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([NH:14][CH:15]3[CH2:17][CH2:16]3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1.[F:18][C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][C:27]=1[N:28]1[C:32]([CH3:33])=[N:31][CH:30]=[N:29]1)[C:22](O)=[O:23]>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([N:14]([CH:15]3[CH2:17][CH2:16]3)[C:22](=[O:23])[C:21]3[CH:25]=[CH:26][C:27]([N:28]4[C:32]([CH3:33])=[N:31][CH:30]=[N:29]4)=[C:19]([F:18])[CH:20]=3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1

参加物

3

反応物 2

HCID 682895731-(5-chloropyrimidin-2-yl)-N-cyclopropylpiperidin-4-amineHCID 682895893-Fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)benzoic acid

生成物 1

HCID 68351917N-[1-(5-Chloro-pyrimidin-2-yl)-piperidin-4-yl]-N-cyclopropyl-3-fluoro-4-(5-methyl-[1,2,4]triazol-1-yl)-benzamide

実験手順

The title compound is prepared from [1-(5-chloro-pyrimidin-2-yl)-piperidin-4-yl]-cyclopropyl-amine and 3-fluoro-4-(5-methyl-[1,2,4]triazol-1-yl)-benzoic acid following a procedure analogous to that described in Example 107. LC (method 19): tR=3.90 min; Mass spectrum (ESI+): m/z=456 [M+H]+.

出典と根拠

ORDレコード
ord-af287c5c58dc469f9c95b226d72ac125
出典データセット
uspto-grants-2014_09
特許番号
US08822471B2

反応ノート

読み込み中…