反応式
B(Br)(Br)Br.ClCCl.ClCCl.[CH2:11]([N:13]1[C:19](=[O:20])[C:18]([CH3:22])([CH3:21])[C:17](=[O:23])[N:16]([CH3:24])[C:15]2[CH:25]=[C:26]([O:29]C)[CH:27]=[CH:28][C:14]1=2)[CH3:12].O>ClCCl.CO.CO>[CH2:11]([N:13]1[C:19](=[O:20])[C:18]([CH3:22])([CH3:21])[C:17](=[O:23])[N:16]([CH3:24])[C:15]2[CH:25]=[C:26]([OH:29])[CH:27]=[CH:28][C:14]1=2)[CH3:12]参加物
7
反応物 4
生成物 1
試薬・触媒・溶媒 2
実験手順
1.0M-boron tribromide/dichloromethane solution (1.22 ml) was added to a dichloromethane solution (3 ml) of 1-ethyl-7-methoxy-3,3,5-trimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione (169 mg) at 0° C. The mixture was stirred at room temperature overnight. Water and methanol were added to the reaction mixture, and extraction was performed using a dichloromethane/methanol mixture (dichloromethane:methanol=10:1). The organic layer was dried over anhydrous sodium sulfate, and condensed to dryness under reduced pressure to give the title compound (156.4 mg) as a white powder.
後処理
- dry with materialThe organic layer was dried over anhydrous sodium sulfate, and condensed to dryness under reduced pressure
出典と根拠
- ORDレコード
- ord-9f866d02a8014aba85fdf27de5334129
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08822453B2
関連ノート
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