Acetic Acid → HCID 70656505、化合物

1-Ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-7-carbaldehyde (0.423 g) and acetic acid (0.14 g) were added to a 1,2-dichloroethane solution (10 ml) of N-(4-methylthiazol-5-ylmethyl)-N-(2-pyridin-3-ylethyl)amine (0.36 g). The mixture was stirred at room temperature for 30 minutes. Sodium triacetoxyborohydride (0.48 g) was added, and the mixture was stirred at room temperature overnight. The reaction liquid was condensed under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:methanol=100:0→50:50). The purified product was condensed under reduced pressure. The residue was washed with diethyl ether, and dried to give the title compound (0.37 g) as a white powder.

1. stirringthe mixture was stirred at room temperature overnight
2. customThe reaction liquid
3. customcondensed under reduced pressure
4. customThe residue was purified by silica gel column chromatography (ethyl acetate:methanol=100:0→50:50)
5. customcondensed under reduced pressure
6. washThe residue was washed with diethyl ether
7. customdried

ORDレコード

ord-32f023bb63584d328554f692b0b18111

出典データセット

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08822453B2