Guaiacol → 2-Methoxyphenyl chloroformate
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1O.CN(C)C1C=CC=CC=1.[C:19]([Cl:22])(Cl)=[O:20].CN(C=[O:27])C>C1(C)C=CC=CC=1.ClC1C=CC=CC=1>[Cl:22][C:19]([O:20][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[O:2][CH3:1])=[O:27]参加物
7
実験手順
A solution of 2-methoxyphenol (2 g, 16.1 mmol), N,N-dimethylaniline (1.95 g, 16.1 mmol), phosgene (8.34 mL of a 1.93 M solution in toluene, 16.1 mmol) and a catalytic amount of DMF in chlorobenzene (5 mL) was stirred in a pressure tube for 2 h at 80° C. The organic layer was separated and concentrated in vacuo. The residue was distilled (Buchi Kugelrohr; bp=115° C. @ 10 mm Hg) to provide 2-methoxyphenyl chloroformate (1.5g; 50%) as a clear oil.
後処理
- customThe organic layer was separated
- concentrationconcentrated in vacuo
- distillationThe residue was distilled (Buchi Kugelrohr; bp=115° C. @ 10 mm Hg)
出典と根拠
- ORDレコード
- ord-d441d990f8a04c2088accbd3027bf473
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07084162B2
反応ノート
読み込み中…