関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Bromo-4-(methylsulphonyl)benzene | HCID 77014 | — |
| 反応物 | tert-Butyl (2R)-2-methylpiperazine-1-carboxylate | HCID 10262201 | — |
| 試薬 | Potassium tert-butoxide | HCID 23665647 | — |
| 触媒 | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| 触媒 | Bis(tri-tert-butylphosphine)palladium(0) | HCID 2734558 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | tert-butyl (2R)-2-methyl-4-(4-methylsulfonylphenyl)piperazine-1-carboxylate | HCID 133499578 | 0% |
反応手順
13-May-09 10:32:28 +0100 1-bromo-4-(methylsulfonyl)benzene (515 mg, 2.13 mmol), (R)-tert-butyl 2-methylpiperazine-1-carboxylate (426 mg, 2.13 mmol) and BIS(TRI-T- BUTYLPHOSPHINE)PALLADIUM(0) (54.3 mg, 0.11 mmol) and potassium 2-methylpropan-2-olate (352 mg, 2.98 mmol) were suspended in dioxane (10 mL) and heated to 90°C for 3 hours. LC-MS shows starting material. Reaction abandoned.
情報源と証拠
| 出典データセット | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-8f20cf3b966d4cdd9e1178539b8e969e |
|---|
| 出典メモ | 750 AstraZeneca ELN dataset |
|---|
