4-Nitro-3-(2-pyrrolidin-1-yl-ethylamino)-benzoic acid methyl ester → HCID 57917314、化合物

HRID 69142ノート

反応式

HRID 69142 の反応式
[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[C:6]([NH:13][CH2:14][CH2:15][N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:5]=1>CO.C1COCC1.[Ni]>[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[C:6]([NH:13][CH2:14][CH2:15][N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:5]=1

参加物

4

反応物 1

HCID 579173564-Nitro-3-(2-pyrrolidin-1-yl-ethylamino)-benzoic acid methyl ester

生成物 1

HCID 57917314HCID 57917314、化合物

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 21899815MeOH tetrahydrofuran溶媒

実験手順

4-Nitro-3-(2-pyrrolidin-1-yl-ethylamino)-benzoic acid methyl ester (xiii) (1.30 g, 4.42 mmol) was shaken in MeOH/THF 1:1 (40 mL) in presence of Raney nickel under 1.1 bar H2 at rt for 40 min. The catalyst was filtered off and washed with MeOH. The filtrate was evaporated to give the title compound as an oil (tR 2.05 min (conditions 8), MH+=264).

後処理

  1. filtrationThe catalyst was filtered off
  2. washwashed with MeOH
  3. customThe filtrate was evaporated

出典と根拠

ORDレコード
ord-f5692c16fcfe4d2895f31b62da87a115
出典データセット
uspto-grants-2014_09
特許番号
US08822468B2

反応ノート

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