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Triethylamine → (6-Chloroimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | [2-(6-Chloro-3-pyridazinyl)-2-azavinyl]dimethylamine | HCID 6802247 | — |
| 反応物 | 2-Bromo-1-(quinolin-6-yl)ethan-1-one | HCID 71699692 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (6-Chloroimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone | HCID 86630275 | — |
反応手順
A mixture of N′-(6-chloro-pyridazin-3-yl)-N,N-dimethyl-formamidine (Stage 1.6, 2 g, 10.8 mmol), 2-bromo-1-quinolin-6-yl-ethanone (Stage 1.3, 3.36 g, 10.8 mmol) and triethylamine (1.1 g, 10.8 mmol) was stirred under reflux for 90 min. The reaction was allowed to cool and water (100 mL) was then added. The resulting red precipitate was filtered off to afford the title compound as a red solid (tR 1.2 min(conditions 1), MH+=309).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822468B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-a3c3b3b4a60845de82fab6907bdca040 |
| 出典メモ | uspto-grants-2014_09 |