Triethylamine → (6-Chloroimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone

HRID 69150

反応式

HRID 69150 の反応式
[Cl:1][C:2]1[N:7]=[N:6][C:5]([N:8]=[CH:9]N(C)C)=[CH:4][CH:3]=1.Br[CH2:14][C:15]([C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[N:23]=[CH:22][CH:21]=[CH:20]2)=[O:16].C(N(CC)CC)C>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:14]([C:15]([C:17]3[CH:18]=[C:19]4[C:24](=[CH:25][CH:26]=3)[N:23]=[CH:22][CH:21]=[CH:20]4)=[O:16])=[CH:9][N:8]=2)[N:7]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 6802247[2-(6-Chloro-3-pyridazinyl)-2-azavinyl]dimethylamineHCID 716996922-Bromo-1-(quinolin-6-yl)ethan-1-one

生成物 1

HCID 86630275(6-Chloroimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of N′-(6-chloro-pyridazin-3-yl)-N,N-dimethyl-formamidine (Stage 1.6, 2 g, 10.8 mmol), 2-bromo-1-quinolin-6-yl-ethanone (Stage 1.3, 3.36 g, 10.8 mmol) and triethylamine (1.1 g, 10.8 mmol) was stirred under reflux for 90 min. The reaction was allowed to cool and water (100 mL) was then added. The resulting red precipitate was filtered off to afford the title compound as a red solid (tR 1.2 min(conditions 1), MH+=309).

後処理

  1. temperatureunder reflux for 90 min
  2. temperatureto cool
  3. filtrationThe resulting red precipitate was filtered off

出典と根拠

ORDレコード
ord-a3c3b3b4a60845de82fab6907bdca040
出典データセット
uspto-grants-2014_09
特許番号
US08822468B2

関連ノート

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