(3R)-(+)-3-(Dimethylamino)pyrrolidine → [(r)-1-(3-Imidazo[1,2-a]pyridin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-pyrrolidin-3-yl]-dimethyl-amine

HRID 69174

反応式

HRID 69174 の反応式
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([CH2:10][C:11]3[N:15]4[N:16]=[C:17](NCCO)[CH:18]=[CH:19][C:14]4=[N:13][CH:12]=3)[CH:7]=[CH:6][C:5]=12.[CH3:24][N:25]([CH3:31])[C@@H:26]1[CH2:30][CH2:29][NH:28][CH2:27]1>>[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([CH2:10][C:11]3[N:15]4[N:16]=[C:17]([N:28]5[CH2:29][CH2:30][C@@H:26]([N:25]([CH3:31])[CH3:24])[CH2:27]5)[CH:18]=[CH:19][C:14]4=[N:13][CH:12]=3)[CH:7]=[CH:6][C:5]=12

参加物

3

反応物 2

HCID 2758521(3R)-(+)-3-(Dimethylamino)pyrrolidineHCID 579173572-(3-Imidazo[1,2-a]pyridin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-ylamino)-ethanol

生成物 1

HCID 44208573[(r)-1-(3-Imidazo[1,2-a]pyridin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-pyrrolidin-3-yl]-dimethyl-amine

実験手順

The title compound was prepared in analogy to the compound of Example 75 using dimethyl(R)-pyrrolidin-3-yl-amine as starting material (tR 0.93 min (conditions 7), MH+=362.1, 1H-NMR in DMSO-d6: 8.48 (s, 1H); 7.86 (s, 1H); 7.76 (d, 1H); 7.52 (s, 1H); 7.46 (d, 1H); 7.37 (s, 1H); 7.19 (d, 1H); 6.78 (d, 1H); 4.17 (s, 2H); 3.63 (m, 2H); 3.35 (m, 1H); 3.16 (m, 1H); 2.78 (m, 1H); 2.18 (m, 7H); 1.81 (m, 1H)).

出典と根拠

ORDレコード
ord-85e327fce7cf45d78eca9f85fac8321b
出典データセット
uspto-grants-2014_09
特許番号
US08822468B2

関連ノート

読み込み中…