関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 6-Phenylnicotinic acid | HCID 120118 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 反応物 | 4-Methoxybutyric acid hydrazide hydrochloride salt | HCID 86590227 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 6-phenylnicotinic acid N'-(4-methoxybutyryl)hydrazide | HCID 69584447 | 65.3% |
反応手順
6-Phenylnicotinic acid (5.90 g) was dissolved in pyridine (150 ml), followed by addition of 4-methoxybutyric acid hydrazide hydrochloride salt (5.99 g) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride salt (8.51 g), and stirred at 60° C. for 10 hours. After the reaction solution was cooled to ambient temperature, the solvent was evaporated under reduced pressure. The resulting residue was washed with water, to afford 6-phenylnicotinic acid N′-(4-methoxybutyryl)hydrazide as pale yellow solid (6.06 g, 65%). The physico-chemical values are as follows.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07084164B2 |
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| 出典データセット | uspto-grants-2006_08 |
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| ORD ID | ord-e17521f35c844b38b7cd816a96b56009 |
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| 出典メモ | uspto-grants-2006_08 |
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