2-Iodoxybenzoic acid → (6-Chloroimidazo[1,2-b]pyridazin-3-yl)(imidazo[1,2-a]pyridin-6-yl)methanone

関与物質

反応手順

(rac)-1-(6-chloro-imidazo[1,2-b]pyridazin-3-yl)-1-(imidazo[1,2-a]pyridin-6-yl)ethanol (Stage 9.1, 5 g, 16.68 mmol) was suspended in acetone (334 mL) with 2-iodoxybenzoic acid (45%, 14.01 g, 22.5 mmol). It was refluxed for 2 h. The RM was then cooled down to rt and the solvent was removed. The residue was triturated with 2.5 N NaOH solution and the precipitated was filtered off and dried to give the title compound as a beige solid (tR 0.6 min (conditions 2), MH+=298).

情報源と証拠