4-Fluorophenylboronic acid → 5-[3,5-bis(trifluoromethyl)benzyl]-7-(4-fluorophenyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine

反応式

[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:6][N:7]2[C:8](=[O:20])[c:9]3[c:10]([n:15][cH:16][cH:17][c:18]3[I:19])[O:11][CH2:12][CH2:13][CH2:14]2)[cH:21][c:22]([C:24]([F:25])([F:26])[F:27])[cH:23]1)([F:28])[F:29].[OH:30][B:31]([OH:32])[c:33]1[cH:34][cH:35][c:36]([F:37])[cH:38][cH:39]1>>[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:6][N:7]2[C:8](=[O:20])[c:9]3[c:10]([n:15][cH:16][cH:17][c:18]3-[c:33]3[cH:34][cH:35][c:36]([F:37])[cH:38][cH:39]3)[O:11][CH2:12][CH2:13][CH2:14]2)[cH:21][c:22]([C:24]([F:25])([F:26])[F:27])[cH:23]1)([F:28])[F:29]

参加物

反応物 2

HCID 2856454-Fluorophenylboronic acid

HCID 114780954-Iodo-6-[3,5-bis(trifluoromethyl)benzyl]-6,7,8,9-tetrahydro-5H-10-oxa-1,6-diazabenzocyclooctene-5-one

生成物 1

HCID 221793545-[3,5-bis(trifluoromethyl)benzyl]-7-(4-fluorophenyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine

出典と根拠

ORDレコード: ord-f8dc17282b96467fbae1e0c8fcf993ed
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…