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Acetone → 6-Butoxy-2-{3-fluoro-4-[(R)-3-(isopropylmethylamino)pyrrolidin-1-yl]phenyl}-3,4-dihydro-2H-isoquinolin-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetone | HCID 180 | — |
| 反応物 | 6-Butoxy-2-[3-fluoro-4-((R)-3-methylaminopyrrolidin-1-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one | HCID 24859577 | — |
| 生成物 | 6-Butoxy-2-{3-fluoro-4-[(R)-3-(isopropylmethylamino)pyrrolidin-1-yl]phenyl}-3,4-dihydro-2H-isoquinolin-1-one | HCID 24859711 | — |
反応手順
6-Butoxy-2-[3-fluoro-4-((R)-3-methylaminopyrrolidin-1-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one (hydrochloride) was reductively alkylated with acetone by method J. The product with the molecular weight of 453.61 (C27H36FN3O2) was obtained in this way; MS (ESI): 454 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822495B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-575e3cc6f39447a2bf39d20582648f94 |
| 出典メモ | uspto-grants-2014_09 |