4-Methoxypiperidine → 2-[4-((R)-3-Dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-6-(4-methoxypiperidin-1-yl)-3,4-dihydro-2H-isoquinolin-1-one

HRID 69415

反応式

HRID 69415 の反応式
[CH3:1][N:2]([CH3:34])[C@@H:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:23][CH2:22][C:21]4[C:16](=[CH:17][CH:18]=[C:19](OS(C(F)(F)F)(=O)=O)[CH:20]=4)[C:15]3=[O:32])=[CH:10][C:9]=2[F:33])[CH2:4]1.[CH3:35][O:36][CH:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1>>[CH3:1][N:2]([CH3:34])[C@@H:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:23][CH2:22][C:21]4[C:16](=[CH:17][CH:18]=[C:19]([N:40]5[CH2:41][CH2:42][CH:37]([O:36][CH3:35])[CH2:38][CH2:39]5)[CH:20]=4)[C:15]3=[O:32])=[CH:10][C:9]=2[F:33])[CH2:4]1

参加物

3

反応物 2

HCID 776664-MethoxypiperidineHCID 86635103Trifluoromethanesulfonic acid 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl ester

生成物 1

HCID 579166882-[4-((R)-3-Dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-6-(4-methoxypiperidin-1-yl)-3,4-dihydro-2H-isoquinolin-1-one

実験手順

Trifluoromethanesulfonic acid 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl ester was reacted with 4-methoxypiperidine by method N. The product with the molecular weight of 466.60 (C27H35FN4O2) was obtained in this way; MS (ESI): 467 (M+H+).

後処理

  1. customThe product with the molecular weight of 466.60 (C27H35FN4O2) was obtained in this way

出典と根拠

ORDレコード
ord-7c25152f79be422db78328987bc7d3ed
出典データセット
uspto-grants-2014_09
特許番号
US08822495B2

関連ノート

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