1-Acetylpiperazine → 2-{4-[3-(4-Acetylpiperazin-1-yl)pyrrolidin-1-yl]phenyl}-6-butoxy-3,4-dihydro-2H-isoquinolin-1-one

反応式

[CH2:1]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[C:12](=[O:16])[N:11]([C:17]1[CH:22]=[CH:21][C:20]([N:23]3[CH2:27][CH2:26][C:25](=O)[CH2:24]3)=[CH:19][CH:18]=1)[CH2:10][CH2:9]2)[CH2:2][CH2:3][CH3:4].[N:29]1([C:35](=[O:37])[CH3:36])[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>>[C:35]([N:29]1[CH2:34][CH2:33][N:32]([CH:25]2[CH2:26][CH2:27][N:23]([C:20]3[CH:21]=[CH:22][C:17]([N:11]4[CH2:10][CH2:9][C:8]5[C:13](=[CH:14][CH:15]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[CH:7]=5)[C:12]4=[O:16])=[CH:18][CH:19]=3)[CH2:24]2)[CH2:31][CH2:30]1)(=[O:37])[CH3:36]

参加物

反応物 2

HCID 837951-Acetylpiperazine

HCID 68988088HCID 68988088、化合物

生成物 1

HCID 579167042-{4-[3-(4-Acetylpiperazin-1-yl)pyrrolidin-1-yl]phenyl}-6-butoxy-3,4-dihydro-2H-isoquinolin-1-one

実験手順

6-Butoxy-2-[4-(3-oxopyrrolidin-1-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one was reacted with 1-piperazin-1-ylethanone by method J. The product with the molecular weight of 490.65 (C29H38N4O3) was obtained in this way; MS (ESI): 491 (M+H+).

後処理

customThe product with the molecular weight of 490.65 (C29H38N4O3) was obtained in this way

出典と根拠

ORDレコード: ord-6a826a81dcd2417bb000a370cbee0968
出典データセット: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08822495B2

反応ノート

読み込み中…