2-(2-Chloroethyl)-4-methoxybenzoyl chloride → 2-[4-(3-Dimethylamino-pyrrolidin-1-yl)-phenyl]-6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one

HRID 69449ノート

反応式

HRID 69449 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]([CH3:15])[CH3:14])[CH2:9]2)=[CH:4][CH:3]=1.Cl[CH2:17][CH2:18][C:19]1[CH:27]=[C:26]([O:28]C)[CH:25]=[CH:24][C:20]=1[C:21](Cl)=[O:22]>>[CH3:14][N:13]([CH3:15])[CH:10]1[CH2:11][CH2:12][N:8]([C:5]2[CH:6]=[CH:7][C:2]([N:1]3[CH2:17][CH2:18][C:19]4[C:20](=[CH:24][CH:25]=[C:26]([OH:28])[CH:27]=4)[C:21]3=[O:22])=[CH:3][CH:4]=2)[CH2:9]1

参加物

3

反応物 2

HCID 124011862-(2-Chloroethyl)-4-methoxybenzoyl chlorideHCID 219165911-(4-aminophenyl)-N,N-dimethylpyrrolidin-3-amine

生成物 1

HCID 689901832-[4-(3-Dimethylamino-pyrrolidin-1-yl)-phenyl]-6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one

実験手順

According to Method A, [1-(4-amino-phenyl)-pyrrolidin-3-yl]-dimethylamine was reacted with 2-(2-chloroethyl)-4-methoxy-benzoyl chloride. The dihydroisoquinolinone thus obtained was treated with hydrogen bromide according to Method L. In this way the product was obtained with molecular weight 351.45 (C21H25N3O2); MS (ESI): 352 (M+H+).

出典と根拠

ORDレコード
ord-bad02b3ce75f4bcaa524b9d91d21c98a
出典データセット
uspto-grants-2014_09
特許番号
US08822495B2

反応ノート

読み込み中…