6-Hydroxy-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one → 2-[4-(4-Methyl-[1,4]diazepan-1-yl)-phenyl]-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one

HRID 69476ノート

反応式

HRID 69476 の反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([C:13]1[CH:18]=[CH:17][C:16]([N:19]3[CH2:25][CH2:24][CH2:23][N:22]([CH3:26])[CH2:21][CH2:20]3)=[CH:15][CH:14]=1)[CH2:6][CH2:5]2.CS([CH2:31][C@H:32]1[CH2:36][CH2:35][CH2:34][O:33]1)(=O)=O>>[CH3:26][N:22]1[CH2:23][CH2:24][CH2:25][N:19]([C:16]2[CH:15]=[CH:14][C:13]([N:7]3[CH2:6][CH2:5][C:4]4[C:9](=[CH:10][CH:11]=[C:2]([O:1][CH2:31][C@H:32]5[CH2:36][CH2:35][CH2:34][O:33]5)[CH:3]=4)[C:8]3=[O:12])=[CH:18][CH:17]=2)[CH2:20][CH2:21]1

参加物

3

反応物 2

HCID 689935356-Hydroxy-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-oneHCID 68993549(R)-2-methanesulfonylmethyl-tetrahydrofuran

生成物 1

HCID 579169602-[4-(4-Methyl-[1,4]diazepan-1-yl)-phenyl]-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one

実験手順

6-Hydroxy-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one and (R)-2-methanesulfonylmethyl-tetrahydrofuran were reacted according to Method K1. In this way the product was obtained with molecular weight 435.57 (C26H33N3O3); MS (ESI): 436 (M+H+).

後処理

  1. customIn this way the product was obtained with molecular weight 435.57 (C26H33N3O3)

出典と根拠

ORDレコード
ord-7bc35f213d944496b5b1860a526a8e02
出典データセット
uspto-grants-2014_09
特許番号
US08822495B2

反応ノート

読み込み中…