関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Lead diacetate | HCID 9317 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 5-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one | HCID 68989306 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | HCID 68991904 | HCID 68991904 | — |
反応手順
A mixture of 5-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one (1.25 g), acetic anhydride (3 mL), lead acetate (3.58 g) and acetic acid (3 mL) was stirred for 48 h at 100° C. After adding sodium carbonate solution it was extracted with ether, dried over magnesium sulfate and concentrated. The residue was chromatographed on silica gel. In this way the product was obtained with molecular weight 290.32 (C16H18O5); MS (ESI): 291 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08822495B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-c20828727c024484b3872a5e0f98f411 |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
