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Isobutylene oxide → 2-{4-[4-(2-Hydroxy-2-methyl-propyl)-[1,4]diazepan-1-yl]-3-methoxy-phenyl}-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-2H-isoquinolin-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isobutylene oxide | HCID 11208 | — |
| 反応物 | 2-(4-[1,4]Diazepan-1-yl-3-methoxy-phenyl)-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-2H-isoquinolin-1-one | HCID 68991377 | — |
| 生成物 | 2-{4-[4-(2-Hydroxy-2-methyl-propyl)-[1,4]diazepan-1-yl]-3-methoxy-phenyl}-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-2H-isoquinolin-1-one | HCID 57916616 | — |
反応手順
Reaction of 2-(4-[1,4]Diazepan-1-yl-3-methoxy-phenyl)-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-2H-isoquinolin-1-one and 2,2-Dimethyl-oxirane by method U resulted in the desired product with the molecular weight 521.66 (C30H39N3O5); MS (ESI): 522 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822495B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-b281c3b373154aa1a23ec1e6f11a12a2 |
| 出典メモ | uspto-grants-2014_09 |