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Hexylene Glycol → 2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-(3-hydroxy-1,3-dimethyl-butoxy)-2H-isoquinolin-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hexylene Glycol | HCID 7870 | — |
| 反応物 | 2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-hydroxy-2H-isoquinolin-1-one | HCID 68989350 | — |
| 生成物 | 2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-(3-hydroxy-1,3-dimethyl-butoxy)-2H-isoquinolin-1-one | HCID 57916769 | — |
反応手順
2-((R)-4-[1,3′]Bipyrrolidinyl-1′-yl-3-fluoro-phenyl)-6-hydroxy-2H-isoquinolin-1-one was reacted with 2-Methyl-pentane-2,4-diol by method Y. The product with the molecular weight of 493.63 (C29H36FN3O3) was obtained in this way; MS (ESI): 494 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822495B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-2d5940d21e804c8880f76ee5740d8177 |
| 出典メモ | uspto-grants-2014_09 |