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4-(Bromomethyl)oxane → 2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-(tetrahydro-pyran-4-ylmethoxy)-2H-isoquinolin-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Bromomethyl)oxane | HCID 2773286 | — |
| 反応物 | 2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-hydroxy-2H-isoquinolin-1-one | HCID 68989350 | — |
| 生成物 | 2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-(tetrahydro-pyran-4-ylmethoxy)-2H-isoquinolin-1-one | HCID 57916900 | — |
反応手順
2-((R)-4-[1,3′]Bipyrrolidinyl-1′-yl-3-fluoro-phenyl)-6-hydroxy-2H-isoquinolin-1-one was reacted with 4-Bromomethyl-tetrahydro-pyran by method K. The product with the molecular weight of 491.61 (C29H34FN3O3) was obtained in this way; MS (ESI): 492 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822495B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-4b83a62b467644a9817b9dcc490d030f |
| 出典メモ | uspto-grants-2014_09 |