Ethylamine → N-ethyl-4-fluorobenzamide
反応式
[CH2:1]([NH2:3])[CH3:2].C(N(CC)CC)C.[F:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=[O:17])=[CH:14][CH:13]=1>C(Cl)Cl.O>[CH2:1]([NH:3][C:16](=[O:17])[C:15]1[CH:19]=[CH:20][C:12]([F:11])=[CH:13][CH:14]=1)[CH3:2]参加物
6
反応条件
- 温度
- 0 °C
実験手順
To a solution of ethylamine (69.4 mL, 139 mmol) and triethylamine (21.10 mL, 151 mmol) in DCM (Volume: 150 mL) was added p-Fluorobenzoyl chloride (15.13 mL, 126 mmol) at 0° C. The reaction was stirred at 0° C. for 1 hr and then warmed slowly to room temperature. The reaction mixture was diluted with water. The layers were separated and the organic layer was washed with brine, dried over MgSO4, filtered, and the organic phase stripped to dryness via rotary evaporation. The organic extract was dried in vacuo to provide N-ethyl-4-fluorobenzamide (21 g, 100% yield) as a tan solid.
後処理
- temperaturewarmed slowly to room temperature
- customThe layers were separated
- washthe organic layer was washed with brine
- dry with materialdried over MgSO4
- filtrationfiltered
- customthe organic phase stripped to dryness via rotary evaporation
- extractionThe organic extract
- customwas dried in vacuo
出典と根拠
- ORDレコード
- ord-c44bb80b96884f6e8d8006369addfabe
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08822470B2
反応ノート
読み込み中…