関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | L-Proline, ethyl ester | HCID 79888 | — |
| 反応物 | 5-Bromo-2-chloro-3-nitropyridine | HCID 7019412 | — |
| 生成物 | (S)-ethyl 1-(5-bromo-3-nitropyridin-2-yl)pyrrolidine-2-carboxylate | HCID 58324356 | 98% |
反応手順
5-bromo-2-chloro-3-nitropyridine (5.94 g, 25 mmol) and (S)-ethyl pyrrolidine-2-carboxylate (7.52 g, 52.5 mmol) were combined and stirred at 90° C. for 10 min in a closed vial. The crude material was purified by flash column chromatography (20-30% EtOAc in hexanes to afford (S)-ethyl 1-(5-bromo-3-nitropyridin-2-yl)pyrrolidine-2-carboxylate (8.43 g, 24.49 mmol, 98% yield) as a yellow viscous oil. [M+H] calc'd for C12H14BrN3O4, 344; found, 344.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08822470B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-bb4a549c5f6f4e35b9cca064c95a6699 |
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| 出典メモ | uspto-grants-2014_09 |
|---|
