関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Piperazine | HCID 4837 | — |
| 反応物 | 4-fluoro-N-methylbenzene-1-sulfonamide | HCID 2440054 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-methyl-4-(piperazin-1-yl)benzene-1-sulfonamide | HCID 23288834 | 87% |
反応手順
4-fluoro-N-methylbenzenesulfonamide (189 mg, 0.999 mmol) and piperazine (430 mg, 4.99 mmol) were combined and the reaction mixture was stirred at 120° C. for 2 h. It was diluted with water (5 mL) and stirred until a fine suspension resulted. The precipitate was filtered, washed with water (5×3 mL) and dried in vacuum to afford N-methyl-4-(piperazin-1-yl)benzenesulfonamide (222 mg, 0.869 mmol, 87% yield) as a white solid. ESI-MS: m/z 256 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08822470B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-8ffc550874ab49deaf3f150f3c66c61d |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
