3-Bromo-4-fluoroaniline → HCID 178505119、化合物

HRID 69766

反応式

HRID 69766 の反応式
[OH:1][NH:2][C:3]([C:5]1[C:9]([NH:10][CH2:11][CH2:12][NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[N:8][O:7][N:6]=1)=[NH:4].[Br:18][C:19]1[CH:20]=[C:21]([CH:23]=[CH:24][C:25]=1[F:26])N>>[Br:18][C:19]1[CH:20]=[C:21]([NH:4][C:3]([C:5]2[C:9]([NH:10][CH2:11][CH2:12][NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[N:8][O:7][N:6]=2)=[N:2][OH:1])[CH:23]=[CH:24][C:25]=1[F:26]

参加物

3

反応物 2

HCID 27792863-Bromo-4-fluoroaniline2 回HCID 178505117N'-hydroxy-4-[2-(methanesulfonamido)ethylamino]-1,2,5-oxadiazole-3-carboximidamide

生成物 1

HCID 178505119HCID 178505119、化合物

実験手順

The title compound was prepared according to the procedure of Example 17 step E, using N-hydroxy-4-({2-[(methylsulfonyl)amino]ethyl}amino)-1,2,5-oxadiazole-3-carboximidamide and 3-bromo-4-fluoroaniline [Oakwood Products, Inc., product #013091] as the starting materials. LCMS for C12H15BrFN6O4S (M+H)+: m/z=437.0, 439.0. 1H NMR (400 MHz, DMSO-d6): δ 11.49 (s, 1H), 8.90 (s, 1H), 7.17 (m, 2H), 7.09 (dd, J=6.3, 2.5 Hz, 1H), 6.26 (t, J=6.1 Hz, 1H), 3.33 (m, 2H), 3.13 (q, J=6.0 Hz, 2H), 2.89 (s, 3H).

出典と根拠

ORDレコード
ord-8f452db05bf64b3a89c22a21330afe6f
出典データセット
uspto-grants-2014_09
特許番号
US08822511B2

関連ノート

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