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4-Chloro-3-nitrobenzophenone → Tert-butyl 4-(4-benzoyl-2-nitrophenyl)piperazine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloro-3-nitrobenzophenone | HCID 41743 | — |
| 反応物 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | Tert-butyl 4-(4-benzoyl-2-nitrophenyl)piperazine-1-carboxylate | HCID 69045013 | 93% |
反応手順
Method 1 was followed using 4-chloro-3-nitrobenzophenone (1.0 eq), 1-Boc-piperazine (1.1 eq), and TEA (2.0 eq) in NMP yielding tert-butyl 4-(4-benzoyl-2-nitrophenyl)piperazine-1-carboxylate (93%). LCMS (m/z): 412.2 (MH+); LC Rt=3.59 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822497B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-6248ee4f40be43a3b83ec9a4dcedc2ad |
| 出典メモ | uspto-grants-2014_09 |