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Benzene, 2-fluoro-4-methyl-1-nitro- → Tert-butyl 4-(5-methyl-2-nitrophenyl)piperazine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| 反応物 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 生成物 | Tert-butyl 4-(5-methyl-2-nitrophenyl)piperazine-1-carboxylate | HCID 69046965 | 97% |
反応手順
Method 1 was followed using 3-fluoro-4-nitrotoluene (1.0 eq), 1-Boc-piperazine (1.2 eq), and TEA (2.0 eq) at 55° C. for 48 hours yielding tert-butyl 4-(5-methyl-2-nitrophenyl)piperazine-1-carboxylate (97%). LCMS (m/z): 322.1 (MH+); LC Rt=3.43 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822497B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-b571b3670865481a964f474ad63eb574 |
| 出典メモ | uspto-grants-2014_09 |