化工社化工社 化学情報印刷レポート · 研究参考用
Benzene, 2-fluoro-4-methyl-1-nitro- → Tert-butyl 1-(5-methyl-2-nitrophenyl)piperidin-4-ylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| 反応物 | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| 生成物 | Tert-butyl 1-(5-methyl-2-nitrophenyl)piperidin-4-ylcarbamate | HCID 69090317 | 97% |
反応手順
Method 1 was followed using 3-fluoro-4-nitrotoluene (1.0 eq), 4-(N-Boc-amino) piperidine (1.2 eq), and TEA (2.0 eq) at 55° C. for 48 hours yielding tert-butyl 1-(5-methyl-2-nitrophenyl)piperidin-4-ylcarbamate (97%). LCMS (m/z): 336.1 (MH+); LC Rt=3.32 min
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822497B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-a7db61b6f3ad431692165270d3381105 |
| 出典メモ | uspto-grants-2014_09 |