Tert-butyl 4-(2-nitro-4-(trifluoromethyl)phenyl)piperazine-1-carboxylate → tert-Butyl 4-[2-amino-4-(trifluoromethyl)phenyl]piperazine-1-carboxylate

HRID 69867

反応式

HRID 69867 の反応式
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[N:14]1[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16][CH2:15]1)([O-])=O>CO>[NH2:1][C:4]1[CH:9]=[C:8]([C:10]([F:12])([F:13])[F:11])[CH:7]=[CH:6][C:5]=1[N:14]1[CH2:15][CH2:16][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:18][CH2:19]1

参加物

3

反応物 1

HCID 53426214Tert-butyl 4-(2-nitro-4-(trifluoromethyl)phenyl)piperazine-1-carboxylate

生成物 1

HCID 53426177tert-Butyl 4-[2-amino-4-(trifluoromethyl)phenyl]piperazine-1-carboxylate収率 99%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Following the method of Example 49 (Method 2), tert-butyl 4-(2-nitro-4-(trifluoro-methyl)phenyl)piperazine-1-carboxylate in MeOH was reduced yielding tert-butyl 4-(2-amino-4-(trifluoromethyl)phenyl)piperazine-1-carboxylate (99%). LCMS (m/z): 346.1 (MH+); LC Rt=3.38 min.

出典と根拠

ORDレコード
ord-05943aaf658c44c99e7446df3ab7a65b
出典データセット
uspto-grants-2014_09
特許番号
US08822497B2

関連ノート

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