(+/-)-4-(3-(Tert-butyl dimethylsilyloxy)piperidin-1-yl)-3-nitropyridine → Tert-butyl (+/-)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amine
反応式
[Si:1]([O:8][CH:9]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[CH:20]=[CH:19][N:18]=[CH:17][C:16]=2[N+:21]([O-])=O)[CH2:10]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]>C(O)C>[C:4]([C:17]1[C:16]([NH2:21])=[C:15]([N:11]2[CH2:12][CH2:13][CH2:14][CH:9]([O:8][Si:1]([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2])[CH2:10]2)[CH:20]=[CH:19][N:18]=1)([CH3:7])([CH3:6])[CH3:5]参加物
3
実験手順
Following Method 2 of Example 49, (+/−)-4-(3-(tert-butyl dimethylsilyloxy)piperidin-1-yl)-3-nitropyridine in ethanol was reduced yielding tert-butyl (+/−)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amine. LCMS (m/z): 308.2 (MH+); LC Rt=3.47 min.
出典と根拠
- ORDレコード
- ord-5c17b6275585471488295f31a3912604
- 出典データセット
- uspto-grants-2014_09