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HRID 69919作成日：2026年10月25日

3-Amino-6-bromopicolinic acid → 3-amino-6-bromo-N-(4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-yl)picolinamide

https://huagongshe.com/reaction/69919

反応式

関与物質

役割名称HCID仕込み量
反応物3-Amino-6-bromopicolinic acidHCID 45480452—
反応物Tert-butyl (+/-)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amineHCID 86669190—
生成物3-amino-6-bromo-N-(4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-yl)picolinamideHCID 86669192—

反応手順

Following Method 11 of Example 305, tert-butyl (+/−)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amine was coupled to 3-amino-6-bromopicolinic acid yielding 3-amino-6-bromo-N-(4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-yl)picolinamide. LCMS (m/z): 506.2 (MH+); LC Rt=4.03 min.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08822497B2
出典データセットuspto-grants-2014_09
ORD IDord-e505b33323204771ad894a072c0bbfe6
出典メモuspto-grants-2014_09