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5-Nitroindole → 5-Aminoindole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Nitroindole | HCID 22523 | — |
| 反応物 | (4-Phenylpiperidin-1-yl)(3,4,5-trimethoxyphenyl)methanone | HCID 39582222 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-Aminoindole | HCID 78867 | 92.5% |
反応手順
A mixture of 5-nitro-1H-indole (11 g, 67.9 mmol) and Pd/C (5%; 1g), dissolved in ethanol (50 mL), was hydrogenated for 3 h at 40 psi. The reaction mixture was filtered and the excess of ethanol was evaporated under reduced pressure. Solid product was recrystallized from hexane to obtain the pure compound 5-aminoindole (55-1). Yield: 92.5%. 1H NMR (500 MHz, CDCl3): δ 7.96 (br, 1H), 7.20 (d, 1H), 7.13 (s, 1H), 6.95 (s, 1H), 6.67 (dd, 1H), 6.37 (s, 1H), 3.50 (s, 2H). MS (ESI) m/z 133.0 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822513B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-ed2f14d75d3b46958858df77ec7402b5 |
| 出典メモ | uspto-grants-2014_09 |