関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 1-(4-Chlorophenyl)piperazine | HCID 97478 | — |
| 反応物 | HCID 178503521 | HCID 178503521 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 178517892 | HCID 178517892 | 92.8% |
反応手順
20.45 g 1-(4-chloro-phenyl)-piperazine are placed in 5.95 ml (104 mmol) glacial acetic acid and heated to 180° C. 8.01 g 2-methylsulphanyl-6,7-dihydro-thieno[3,2-d]pyrimidin-4-ol are added, the non-stirrable reaction mixture is heated for 2.5 hours to 180° C. After cooling, water is added, the precipitate is suction filtered and dried in the air. The substance is treated with ethanol under ultrasound, suction filtered and dried. 12.95 g of the product are obtained as a powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08822474B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-115cf9f5eb3a4b0b9a4d930d5c814dda |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
