4-Nitrophenyl chloroformate → 4-nitrophenyl 2,3-dihydro-1H-inden-5-ylcarbamate

HRID 70158

反応式

HRID 70158 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH2:6][CH2:5]2.Cl[C:12]([O:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1)=[O:13]>C(Cl)Cl>[CH2:7]1[C:8]2[C:4](=[CH:3][C:2]([NH:1][C:12](=[O:13])[O:14][C:15]3[CH:16]=[CH:17][C:18]([N+:21]([O-:23])=[O:22])=[CH:19][CH:20]=3)=[CH:10][CH:9]=2)[CH2:5][CH2:6]1

参加物

4

反応物 2

HCID 821294-Nitrophenyl chloroformateHCID 90496Indan-5-amine

生成物 1

HCID 152372784-nitrophenyl 2,3-dihydro-1H-inden-5-ylcarbamate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

5-Aminoindan (212 mg, 1.59 mmol) was dissolved in CH2Cl2 (10 mL), p-nitrophenyl chloroformate (417 mg, 2.07 mmol) was added, and the reaction mixture was stirred at rt overnight. The solid was removed by filtration (discarded), and the filtrate was concentrated under reduced pressure. This gave the title compound as a grey solid which was about 50% pure and was used without further purification. LC-MS: RT=9.98 min, [M+H]+=299.1.

後処理

  1. customThe solid was removed by filtration (discarded)
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-9676e16e40bc47fe918cc08e4df9cd8f
出典データセット
uspto-grants-2014_09
特許番号
US08822472B2

関連ノート

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