(+)-cis-2-Benzamidocyclohexanecarboxylic Acid → (1S,2R)-2-aminocyclohexane-1-carboxylic acid
反応式
C([NH:9][C@@H:10]1[CH2:15][CH2:14][CH2:13][CH2:12][C@@H:11]1[C:16]([OH:18])=[O:17])(=O)C1C=CC=CC=1>Cl>[NH2:9][C@@H:10]1[CH2:15][CH2:14][CH2:13][CH2:12][C@@H:11]1[C:16]([OH:18])=[O:17]参加物
3
実験手順
A mixture of (+)-(1S,2R)-2-benzamidocyclohexanecarboxylic acid (4.0 g, 16.2 mmol, TCI chemical company) and 6 M hydrochloric acid (200 mL) was heated at reflux for 48 h. The reaction mixture was cooled to room temperature and extracted with diethyl ether (2×200 mL). The aqueous portion was concentrated in vacuo to afford (1S,2R)-2-aminocyclohexanecarboxylic acid as a white solid. The crude product was used in the next step without purification or characterization.
後処理
- temperaturewas heated
- temperatureat reflux for 48 h
- extractionextracted with diethyl ether (2×200 mL)
- concentrationThe aqueous portion was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-7b337e6af2f0449cad27ae97895f7ad8
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07084178B2
反応ノート
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