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D-Psicose → Methyl 2-amino-4-(methylthio)benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | D-Psicose | HCID 441036 | — |
| 反応物 | 4-Methylsulfanyl-2-nitro-benzoic acid methyl ester | HCID 13988044 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Platinum sulfide (PtS) | HCID 82861 | — |
| 溶媒 | Methyl Acetate | HCID 6584 | — |
| 生成物 | Methyl 2-amino-4-(methylthio)benzoate | HCID 13988045 | — |
反応手順
A mixture of methyl 4-(methylthio)-2-nitrobenzoate (11.3 g. 49.7 mmol) and 5% platinum sulfide on carbon catalyst (0.7 g) in methyl acetate (40 mL) was hydrogenated at 750 Psi and 75° C. until hydrogen uptake ceased. The mixture was filtered through Celite®, and the filtrate solvent was rotary evaporated, leaving methyl 2-amino-4-(methylthio)benzoate as a slightly tan crystalline solid (8.7 g) melting at 57°-59° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04981509 |
| 出典データセット | uspto-grants-1991_01 |
| ORD ID | ord-d2456382c81b41cba50b4677bd80b183 |
| 出典メモ | uspto-grants-1991_01 |