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2-Propenenitrile, 3-hydroxy- → 3-(2,3-Dichlorophenacylamino)acrylonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Propenenitrile, 3-hydroxy- | HCID 3054073 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | Ethanone, 2-amino-1-(2,3-dichlorophenyl)-, hydrochloride | HCID 22151845 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(2,3-Dichlorophenacylamino)acrylonitrile | HCID 67944094 | — |
反応手順
2 g of 2,3-dichlorophenacylamine hydrochloride, 1 g of 3-hydroxyacrylonitrile, sodium salt, and 20 ml of ethanol are heated for 2 hours under reflux. The reaction mixture is concentrated by evaporation and the oily residue is purified by column chromatography (silica gel; elution with a 4:1 mixture of toluene/ethyl acetate), affording 3-(2,3-dichlorophenacylamino)acrylonitrile in the cis/trans ratio of 5:1. Melting point: 122°-125° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04981990 |
| 出典データセット | uspto-grants-1991_01 |
| ORD ID | ord-296fccb88ba5466da8ea50a16aeef931 |
| 出典メモ | uspto-grants-1991_01 |