化工社化工社 化学情報印刷レポート · 研究参考用
(3-Carbamoylphenyl)boronic acid → 4'-Cyano-2'-(trifluoromethyl)-3-biphenylcarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (3-Carbamoylphenyl)boronic acid | HCID 2737814 | — |
| 反応物 | 4-Iodo-3-(trifluoromethyl)benzonitrile | HCID 22625194 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Toluene ethanol | HCID 21863594 | — |
| 生成物 | 4'-Cyano-2'-(trifluoromethyl)-3-biphenylcarboxamide | HCID 67160792 | — |
反応手順
The title compound was synthesized from 3-(aminocarbonyl)phenyl boronic acid and 4-iodo-3-(trifluoromethyl)benzonitrile (I-IX-6) according to the procedure described for Ex IX-10, using Pd(PPh3)4 catalyst and PhMe/EtOH (4:1) as organic cosolvents. LC/MS (method A) 2.18 min, m/z 291 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822518B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-7642abc52f4148488e8c55089de794d1 |
| 出典メモ | uspto-grants-2014_09 |