Hydrochloric Acid → HCID 86744465、化合物

HRID 703280

反応式

HRID 703280 の反応式
C([NH:9][CH2:10][C@@H:11]([C@H:16]([OH:18])[CH3:17])[C:12]([O:14]C)=[O:13])(=O)C1C=CC=CC=1.[ClH:19]>>[ClH:19].[NH2:9][CH2:10][C@@H:11]([C@H:16]([OH:18])[CH3:17])[C:12]([OH:14])=[O:13]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 10060699(2S,3R)-methyl-2-benzamidomethyl-3-hydroxybutyrate

生成物 1

HCID 86744465HCID 86744465、化合物収率 93%

実験手順

To 10.65 g (42.43 mmole) of methyl (2S, 3R)-2-(N-benzoylamino)methyl-3-hydroxybutanoate was added 70 ml of a 10% hydrochloric acid aqueous solution at room temperature to form a solution. The solution was heated at reflux for 4.5 hours and then allowed to cool to room temperature. The precipitated benzoic acid was separated by filtration, and the filtrate was washed twice with 100 ml portions of toluene. The aqueous layer was concentrated under reduced pressure to obtain 6.67 g (yield: 93%) of (2S, 3R)-2-aminomethyl-3-hydroxybutanoic acid hydrochloride.

後処理

  1. customto form a solution
  2. temperatureThe solution was heated
  3. temperatureat reflux for 4.5 hours
  4. customThe precipitated benzoic acid was separated by filtration
  5. washthe filtrate was washed twice with 100 ml portions of toluene
  6. concentrationThe aqueous layer was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-b82bab42b2c1419abdb6c1462a26f5ac
出典データセット
uspto-grants-1991_01
特許番号
US04981992

関連ノート

読み込み中…