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(3-Carbamoylphenyl)boronic acid → 4'-(1,3-Dioxolan-2-yl)-3'-(trifluoromethyl)-3-biphenylcarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (3-Carbamoylphenyl)boronic acid | HCID 2737814 | — |
| 反応物 | 2-[4-Iodo-2-(trifluoromethyl)phenyl]-1,3-dioxolane | HCID 58276681 | — |
| 溶媒 | Toluene ethanol | HCID 21863594 | — |
| 生成物 | 4'-(1,3-Dioxolan-2-yl)-3'-(trifluoromethyl)-3-biphenylcarboxamide | HCID 67159994 | — |
反応手順
The title compound was prepared from 3-(aminocarbonyl)phenyl boronic acid and 2-[4-iodo-2-(trifluoromethyl)phenyl]-1,3-dioxolane (I-IX-7) according to the procedure described for IX-10, using PhMe/EtOH (4:1) as organic cosolvents. Colorless solid. LC/MS (method A) 2.38 min; m/z 338 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822518B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-46ac662b190145d0b275375fff7109d3 |
| 出典メモ | uspto-grants-2014_09 |