2-Bromopropan-1-ol → Phosphorodichloridic acid-2-bromopropyl ester

HRID 703316ノート

反応式

HRID 703316 の反応式
[P:1]([Cl:5])(Cl)([Cl:3])=[O:2].[Br:6][CH:7]([CH3:10])[CH2:8][OH:9]>C(Cl)(Cl)(Cl)Cl>[Br:6][CH:7]([CH3:10])[CH2:8][O:9][P:1]([Cl:5])([Cl:3])=[O:2]

参加物

4

反応物 2

HCID 117132-Bromopropan-1-olHCID 24813Phosphorus oxychloride

生成物 1

HCID 14256196Phosphorodichloridic acid-2-bromopropyl ester収率 56.7%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒2 回

実験手順

To a solution of 42 g of phosphorous oxychloride in 110 ml of carbon tetrachloride was added dropwise with stirring a solution of 25 g of 2-bromo-1-propanol in 25 ml of carbon tetrachloride. This mixture was stirred overnight, then taken to dryness, evaporated twice from toluene and dried. The residue was distilled on a Kugelrohr 75° C., 0.05 mm, giving 26.1 g of the desired compound as a colorless oil.

後処理

  1. customevaporated twice from toluene
  2. customdried
  3. distillationThe residue was distilled on a Kugelrohr 75° C., 0.05 mm

出典と根拠

ORDレコード
ord-5a3e9f938ce34d07b012d5b8f02f03df
出典データセット
uspto-grants-1991_01
特許番号
US04981989

反応ノート

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