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Dichloromethane → 3-(2,2,3,3,3-Pentafluoropropoxy)methyl-4-methyl-1-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | 2,2,3,3,3-Pentafluoropropanol | HCID 9872 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 2-(Chloromethyl)-1-methyl-4-nitrobenzene | HCID 187952 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-(2,2,3,3,3-Pentafluoropropoxy)methyl-4-methyl-1-nitrobenzene | HCID 15070168 | — |
反応手順
In 16.5 ml of dimethylformamide, 5.00 g (0.027 mol) of 2-methyl-5-nitrobenzyl chloride and 21.3 g (0.135 mol) of 2,2,3,3,3-pentafluoropropanol were dissolved. The solution was then added with 2.29 g (0.041 mol) of KOH pellets and stirred overnight. Dichloromethane was added and the precipitated salts were filtered out. The filtrate was acidified with dilute hydrochloric acid and then the solvents were distilled off.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04983209 |
| 出典データセット | uspto-grants-1991_01 |
| ORD ID | ord-fe6198eb9b0a45a8ba52b72219df5ea0 |
| 出典メモ | uspto-grants-1991_01 |