関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Glutaric Acid | HCID 743 | — |
| 反応物 | Glyoxylylspermidine | HCID 133564 | — |
| 反応物 | HCID 178479426 | HCID 178479426 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 178478607 | HCID 178478607 | 87.9% |
反応手順
A mixture of 202.4 mg (0.86 mmole) of 8-guanidino-2-octenamide hydrochloride, 302.4 mg (1.04 mmoles) of N-[4-(3-aminopropyl)aminobutyl]-2,2-dihydroxyethanamide dihydrochloride, 113.9 mg (0.86 mmole) of glutaric acid and 0.2 ml of water was heated at 60° C. for 24 hours. After completion of the reaction the reaction mixture was purified in a manner similar to that in Example 1 using CM-Sephadex® C-25 (Na-type) and Sephadex® LH-20 to obtain 128.3 mg (29.2% yield) of N-[4-(3-aminopropyl)aminobutyl]-2-(8-guanidino-2-octenamido)-2-hydroxyethanamide trihydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04983328 |
|---|
| 出典データセット | uspto-grants-1991_01 |
|---|
| ORD ID | ord-1773da0784c74eec91cc9adc99e81f1b |
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| 出典メモ | uspto-grants-1991_01 |
|---|
