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Diisopropylethylamine → N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-thiophenecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Quinuclidine, 3-amino-, dihydrochloride | HCID 197853 | — |
| 反応物 | N-(Aminocarbonyl)-2-thiophenecarboxamide | HCID 395032 | — |
| 反応物 | Maleate(2-) | HCID 5288227 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-thiophenecarboxamide | HCID 15616403 | — |
反応手順
The above compound was prepared, following the procedure of Example 14b, from 3-aminoquinuclidine dihydrochloride (1.0 g, 5 mmol), 2-thienoylurea (0.85 g, 5 mmol) and diisopropylethylamine (1.3 g, 10 mmol) in pyridine (20 ml). The product (0.79 g) was converted to hydrochloride half hydrate, mp 232°-233° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04983600 |
| 出典データセット | uspto-grants-1991_01 |
| ORD ID | ord-f5c9b0a985694562aec02036d1803a0f |
| 出典メモ | uspto-grants-1991_01 |