Chloroform ether → 2-(3-chloropropyl)-6,7-dimethoxy-1(2H)-phthalazinone

HRID 703454ノート

反応式

HRID 703454 の反応式
O[CH2:2][CH2:3][N:4]1[N:13]=[CH:12][C:11]2[C:6](=[CH:7][C:8]([O:16][CH3:17])=[C:9]([O:14][CH3:15])[CH:10]=2)[C:5]1=[O:18].OCCCN1N=CC2C(=CC(OC)=C(OC)C=2)C1=O.[CH:38](Cl)(Cl)[Cl:39].C(OCC)C>>[Cl:39][CH2:38][CH2:2][CH2:3][N:4]1[N:13]=[CH:12][C:11]2[C:6](=[CH:7][C:8]([O:16][CH3:17])=[C:9]([O:14][CH3:15])[CH:10]=2)[C:5]1=[O:18]

参加物

4

反応物 3

HCID 21911965Chloroform etherHCID 221501572-(2-hydroxyethyl)-6,7-dimethoxy-1(2H)-phthalazinoneHCID 221501672-(3-hydroxypropyl)-6,7-dimethoxy-1(2H)-phthalazinone

生成物 1

HCID 221501712-(3-chloropropyl)-6,7-dimethoxy-1(2H)-phthalazinone

実験手順

Working as described in Example 2 but replacing 2-(2-hydroxyethyl)-6,7-dimethoxy-1(2H)-phthalazinone with an equivalent amount of 2-(3-hydroxypropyl)-6,7-dimethoxy-1(2H)-phthalazinone obtained as described in Example 12, 2-(3- chloropropyl)-6,7-dimethoxy-1(2H)-phthalazinone is obtained (m.p. 185°-187° C., from chloroform/ethyl ether).

後処理

  1. customobtained

出典と根拠

ORDレコード
ord-e9750e8b6eba4551b11f64ca69604883
出典データセット
uspto-grants-1991_01
特許番号
US04983606

反応ノート

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