Hydrochloric Acid → Zofran

HRID 703503

反応式

HRID 703503 の反応式
[CH3:1][N:2]1[C:14]2[CH2:13][CH2:12][CH:11]([CH2:15][N:16]3[CH:20]=[CH:19][N:18]=[C:17]3[CH3:21])[C:10](=[O:22])[C:9]=2[C:8]2[C:3]1=[CH:4][CH:5]=[CH:6][CH:7]=2.C([OH:26])(C)C.[ClH:27]>O>[OH2:22].[OH2:26].[ClH:27].[CH3:1][N:2]1[C:14]2[CH2:13][CH2:12][CH:11]([CH2:15][N:16]3[CH:20]=[CH:19][N:18]=[C:17]3[CH3:21])[C:10](=[O:22])[C:9]=2[C:8]2[C:3]1=[CH:4][CH:5]=[CH:6][CH:7]=2

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 4595Ondansetron

生成物 1

HCID 59774Zofran

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one (18.3 g) in a hot mixture of isopropanol (90 ml) and water (18.3 ml) was treated with concentrated hydrochloric acid (6.25 ml). The hot mixture was filtered and the filtrate diluted with isopropanol (90 ml) and stirred at room temperature for 17 h, cooled to 2° and the solid filtered off (21.6 g). A sample (6 g) was recrystallised from a mixture of water (6 ml) and isopropanol (10 ml) to give the title compound as a white crystalline solid (6 g) m.p. 178.5°-179.5°.

後処理

  1. filtrationThe hot mixture was filtered
  2. additionthe filtrate diluted with isopropanol (90 ml)
  3. temperaturecooled to 2°
  4. filtrationthe solid filtered off (21.6 g)
  5. customA sample (6 g) was recrystallised from a mixture of water (6 ml) and isopropanol (10 ml)

出典と根拠

ORDレコード
ord-546df3d2d01d41bfbababff159617165
出典データセット
uspto-grants-1991_01
特許番号
US04983621

関連ノート

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