化工社化工社 化学情報印刷レポート · 研究参考用
2-(2-Hydroxyethyl)pyridine → 2-(2-Chloroethyl)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(2-Hydroxyethyl)pyridine | HCID 7675 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-(2-Chloroethyl)pyridine | HCID 199468 | — |
反応手順
2-(Pyridin-2-yl)ethanol (1 g, 8.12 mmol) was first treated with SOCl2 (3 ml) in CH2Cl2 (10 ml) at rt for 3 hrs. The solvent was removed to get a crude 2-(2-chloroethyl)pyridine. Then following General Procedure A, the title compound (1.69 g, 79%) was prepared from 2-amino-4-chlorobenzenethiol (1.6 g, 9.74 mmol), K2CO3 (3.36 g, 24.36 mmol) in DMF (20 ml).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822530B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-14df6d8978a74be6b50b48bfcb9d619f |
| 出典メモ | uspto-grants-2014_09 |