化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl Acetate → methyl 5-formyl-(R)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-pentanecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Ozone | HCID 24823 | — |
| 反応物 | methyl (R)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-6-heptenoate | HCID 86743990 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 生成物 | methyl 5-formyl-(R)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-pentanecarboxylate | HCID 86743989 | — |
反応手順
A solution of 2.56 g of methyl (R)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-6-heptenoate in 40 ml of ethyl acetate is treated with ozone at -75° C. After the reaction has finished 0.1 g of Pd-on-carbon is added thereto and the mixture is hydrogenated at room temperature. After the hydrogen uptake has finished one filters off the catalyst, washes with ethyl acetate and evaporates in vacuo. There is obtained crude methyl 5-formyl-(R)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-pentanecarboxylate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04983746 |
| 出典データセット | uspto-grants-1991_01 |
| ORD ID | ord-5d9d0b90eb424adb83865c33781a2d11 |
| 出典メモ | uspto-grants-1991_01 |