Imidazole → HCID 54125133、化合物

HRID 703690ノート

反応式

HRID 703690 の反応式
[OH:1][C@@H:2]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:3][C:4]([O:6][CH3:7])=[O:5].[C:19]([Si:23]([CH3:26])([CH3:25])Cl)([CH3:22])([CH3:21])[CH3:20].N1C=CN=C1.O>CN(C=O)C>[O:1]([C@@H:2]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:3][C:4]([O:6][CH3:7])=[O:5])[Si:23]([C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:26])[CH3:25]

参加物

6

反応物 4

HCID 795ImidazoleHCID 962WaterHCID 28928tert-Butyldimethylsilyl chlorideHCID 11021563(S)-Methyl 3-hydroxytetradecanoate

生成物 1

HCID 54125133HCID 54125133、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

12.9 g of methyl (S)-3-hydroxytetradecanoate are dissolved in 50 ml of DMF under argon 9.0 g of t-butyldimethylchlorosilane are added thereto, 8.5 g of imidazole are then added portionwise and the mixture is left to stir for 17 hours. The reaction mixture is poured into 300 ml of water and extracted three times with 50 ml of diethyl ether. The combined organic phases are dried, filtered and evaporated. By distillation at 140°-145° C./0.07 mm there is obtained methyl (S)-3-(t-butyldimethylsiloxy)tetradecanoate as a colourless oil.

後処理

  1. additionare added
  2. waitthe mixture is left
  3. extractionextracted three times with 50 ml of diethyl ether
  4. customThe combined organic phases are dried
  5. filtrationfiltered
  6. customevaporated
  7. distillationBy distillation at 140°-145° C./0.07 mm there

出典と根拠

ORDレコード
ord-e69bdbfec3d94c208e29eeb7e1582426
出典データセット
uspto-grants-1991_01
特許番号
US04983746

反応ノート

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